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Reviews and User Ratings: Effectiveness, Ease of Use, and SatisfactionYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Some of these opinions may contain information about treatment or uses of drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Levaquin: 266 user reviews - DailyStrength Join | Help | Sign In 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Levofloxacin is effective against a number of gram-positive and gram-negative bacteria. Because of its broad spectrum of action, levofloxacin is frequently prescribed empirically for a wide range of infections (e.g. pneumonia, urinary tract infection) before the specific causal organism is known. If the causal organism...more at Wikipedia Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature From the Departments of Internal Medicine (LG) and Dermatology (HI), Mount Sinai Medical Center, Miami Beach, Florida, and Private Practice of Dermatology, Miami Beach, Florida Treatment with the fluoroquinolone class of antibiotics has become increasingly popular. Clinician preference for quinolones stems from their excellent gastrointestinal absorption, superior tissue penetration and broad-spectrum activity.1,2 However, this has led to widespread and indiscriminate use, affecting microbial resistance patterns and increasing drug-related morbidity.3 Although quinolone-induced tendonopathy and tendon rupture have been previously described in the literature, reports of tendon rupture in association with newer quinolones such as levofloxacin are now emerging.4,5 We describe a patient with levofloxacin-induced partial rupture of the Achilles tendon and review the literature, pathophysiology, predisposing factors, and treatment recommendations. Although quinolone-induced tendon rupture has been described in the literature,6,7 case reports of complete or partial tendon rupture specifically attributed to levofloxacin are rare thus far.4,5 Quinolone-induced tendonopathy was noted as early as 1983; Bailey et al8 reported a norfloxacin-related tendonitis in a patient with kidney failure. The first case of a tendon rupture associated with ciprofloxacin was reported in 1987.9 A pefloxacin-related tendon rupture reported in 1991 led to the published recognition of this complication in the VIDAL (French PDR) in 1992.1 In October 1996, the US Food and Drug Administration first issued a Report of Adverse Events and revised the class labeling for fluoroquinolones to include a warning of possible tendonitis/tendon rupture after more than 200 reports of quinolone-related tendonopathy over a 10-year period.
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